Centrosomes vs Telomeres

Back on September 1, I wrote a few words on Telomeres, sequences of  with a link for further information.  Here is an article on the companion of the telomere: the centrosome – carlos

Art of Dividing: Researchers Decode Function and Protein Content of the Centrosome

ScienceDaily (Sep. 2, 2010) — A basic requirement for growth and life of a multicellular organism is the ability of its cells to divide. Chromosomes in the cells duplicate and are then distributed among the daughter cells. This distribution is organized by a protein complex made up of several hundred different proteins, called the centrosome. In cancer cells, the centrosome often assumes an unnatural shape or is present in uncontrolled numbers. The reasons for this were previously largely unknown.

Scientists at the Max Planck Institute for Molecular Genetics in Berlin, together with colleagues at the German Cancer Research Center in Heidelberg and at the Leibniz Institute for Age Research — Fritz Lipmann Institute in Jena, have investigated the functions of the different centrosomal components. The researchers led by Bodo Lange now present their results in theEMBO Journal, detailing the centrosome’s components and their functions. Their work extends our knowledge of regulation of cell division and opens the door to new investigations into cancer development.

As part of their research, the scientists examined centrosomes of the fruit fly Drosophila as well as those from human cells. “The fruit fly is a terrific system for investigating the centrosome, because the basic mechanisms of cell division are very similar between fly and human,” Bodo Lange, the research group leader, explains.

The group isolated centrosomes from the eggs of fruit flies and, using mass spectrometry methods, identified more than 250 different proteins making up this complex. These components were then subjected to targeted inactivation through RNA interference (RNAi), to discover their role in the structure of the centrosome and in chromosome distribution. The scientists were able to determine the protein functions quantitatively through use of state-of-the-art automatic and robotic microscopes. They found a whole series of proteins responsible for the separation of chromosomes, number of centrosomes and their structure. As these characteristics are often disrupted in cancer cells, the researchers believe their findings will have a significant impact on the understanding of cell division and the development of cancerous diseases.

The work of these scientists has brought new insight into the abnormalities seen in cancer cells. “Based on our findings, we hope to be able to unravel regulatory networks in the future, which will help to target and interfere with the division of cancer cells.”== == ==

There is an excellent NIMH article regarding the evolution of centromeres and telomeres.


About carlos

I'm a curious person, of reasonable intellect, "on the beach" (retired) and enjoying my interest in anthropology, language, civil rights, and a few other areas. I've been a hippie/student/aerospace tech writer in the '60s, a witness to the Portuguese revolution in the ‘70s, a defense test engineer and witness to the Guatemalan genocide in the '80s, and a network engineer for an ISP in the '90s. Now I’m a student and commentator until my time is up. I've spent time under the spell of the Mesoamerican pyramids and the sweet sound of the Portuguese language. I've lived in Europe, traveled in Brazil, Central America, Iceland, New Zealand, and other places. My preferred mode of travel is with a backpack and I eat (almost) anything local. Somehow, many of the countries I have been to have had civil unrest (for which I was not responsible). I'm open to correspond with anyone who might share my liberal, humanist interests. I live in San Buenaventura, California.
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